Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Egile Nagusiak: Jian Xin (Egilea), Min Hu (Egilea), Qian Liu (Egilea), Tian Tai Zhang (Egilea), Dong Mei Wang (Egilea), Song Wu (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...