Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Päätekijät: Jian Xin (Tekijä), Min Hu (Tekijä), Qian Liu (Tekijä), Tian Tai Zhang (Tekijä), Dong Mei Wang (Tekijä), Song Wu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...