Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Auteurs principaux: Jian Xin (Auteur), Min Hu (Auteur), Qian Liu (Auteur), Tian Tai Zhang (Auteur), Dong Mei Wang (Auteur), Song Wu (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...