Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• मुख्य लेखकों: Jian Xin (लेखक), Min Hu (लेखक), Qian Liu (लेखक), Tian Tai Zhang (लेखक), Dong Mei Wang (लेखक), Song Wu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...