Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Autori principali: Jian Xin (Autore), Min Hu (Autore), Qian Liu (Autore), Tian Tai Zhang (Autore), Dong Mei Wang (Autore), Song Wu (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...