Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• 主要な著者: Jian Xin (著者), Min Hu (著者), Qian Liu (著者), Tian Tai Zhang (著者), Dong Mei Wang (著者), Song Wu (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...