Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Главные авторы: Jian Xin (Автор), Min Hu (Автор), Qian Liu (Автор), Tian Tai Zhang (Автор), Dong Mei Wang (Автор), Song Wu (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предметы: article
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Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...