Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Asıl Yazarlar: Jian Xin (Yazar), Min Hu (Yazar), Qian Liu (Yazar), Tian Tai Zhang (Yazar), Dong Mei Wang (Yazar), Song Wu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...