Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

• Những tác giả chính: Jian Xin (Tác giả), Min Hu (Tác giả), Qian Liu (Tác giả), Tian Tai Zhang (Tác giả), Dong Mei Wang (Tác giả), Song Wu (Tác giả)
• Định dạng: Sách
• Được phát hành: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The...