Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

• Hauptverfasser: Andrea Raposo Lopez-Pastor (Verfasst von), Almudena Gomez-Hernandez (Verfasst von), Sabela Diaz-Castroverde (Verfasst von), Gloria Gonzalez-Aseguinolaza (Verfasst von), Agueda Gonzalez-Rodriguez (Verfasst von), Gema Garcia (Verfasst von), Silvia Fernandez (Verfasst von), Oscar Escribano (Verfasst von), Manuel Benito (Verfasst von)
• Format: Buch
• Veröffentlicht: The Company of Biologists, 2019-02-01T00:00:00Z.
• Schlagworte: article
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Among the main complications associated with obesity are insulin resistance and altered glucose and lipid metabolism within the liver. It has previously been described that insulin receptor isoform A (IRA) favors glucose uptake and glycogen storage in hepatocytes compared with isoform B (IRB), impro...