Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

• Main Authors: Chang-Lung Lee (Author), Everett J. Moding (Author), Xiaofang Huang (Author), Yifan Li (Author), Loretta Z. Woodlief (Author), Rafaela C. Rodrigues (Author), Yan Ma (Author), David G. Kirsch (Author)
• Format: Book
• Published: The Company of Biologists, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The site-specific recombinases Cre and Flp can mutate genes in a spatially and temporally restricted manner in mice. Conditional recombination of the tumor suppressor gene p53 using the Cre-loxP system has led to the development of multiple genetically engineered mouse models of human cancer...