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Local Epidemiology of Nosocomial <i>Staphylococcus aureus</i> Infection in a Nigerian University Teaching Hospital

Population-based studies of <i>Staphylococcus aureus</i> contribute to understanding the epidemiology of <i>S. aureus</i> infection. We enrolled surgical inpatients admitted to an African tertiary-care hospital in order to prospectively analyze the nosocomial impact of <i&...

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Main Authors: Adeniran Adeyanju (Author), Frieder Schaumburg (Author), Adedeji Onayade (Author), Akinyele Akinyoola (Author), Taofeeq Adeyemi (Author), Osaretin Ugbo (Author), Robin Köck (Author), Yemisi Amusa (Author), Oladejo Lawal (Author), Temilade Adeyanju (Author), Nkem Torimiro (Author), David Akinpelu (Author), Deboye Kolawole (Author), Christian Kohler (Author), Karsten Becker (Author)
Format: Book
Published: MDPI AG, 2022-10-01T00:00:00Z.
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Summary:Population-based studies of <i>Staphylococcus aureus</i> contribute to understanding the epidemiology of <i>S. aureus</i> infection. We enrolled surgical inpatients admitted to an African tertiary-care hospital in order to prospectively analyze the nosocomial impact of <i>S. aureus</i>. Data collection included an active sampling of the anterior nares and infectious foci within 48 h after admission and subsequently when clinically indicated. All <i>S. aureus</i> isolates were <i>spa</i> and <i>agr</i> genotyped. Possession of Panton-Valentine leukocidin (PVL) and other toxin genes was determined. We analyzed antibiotic susceptibility profiles by VITEK 2 systems and verified methicillin-resistant <i>S. aureus</i> (MRSA) by <i>mecA/C</i> PCR. Among 325 patients, 15.4% carried methicillin-susceptible <i>S. aureus</i> (MSSA) at admission, while 3.7% carried MRSA. The incidence densities of nosocomial infections due to MSSA and MRSA were 35.4 and 6.2 infections per 10,000 patient-days, respectively. Among all 47 nosocomial infections, skin and soft-tissue (40.4%) and bones or joints' (25.5%) infections predominated. Six (12.7%) infection-related <i>S. aureus</i> isolates harbored PVL genes including two (4.2%) MRSA: overall, seventeen (36.2%) isolates carried pyrogenic toxin superantigens or other toxin genes. This study illustrates the considerable nosocomial impact of <i>S. aureus</i> in a Nigerian University hospital. Furthermore, they indicate a need for effective approaches to curtail nosocomial acquisition of multidrug-resistant <i>S. aureus</i>.
Item Description:10.3390/antibiotics11101372
2079-6382

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