CLINICAL SIGNIFICANCE OF HEART RATE VARIABILITY INDEXES DERIVED FROM 5-MINUTE AND 24-HOUR ECG RECORDINGS IN PATIENTS WITH RHEUMATOID ARTHRITIS
<p><strong>Aim.</strong> To estimate heart rate variability (HRV) from 5-min and 24-h electrocardiogram (ECG) recordings in female patients with rheumatoid arthritis (RA) and patients of control group, to analyze association between HRV indexes and cardiovascular risk factors and R...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Published: |
Столичная издательская компания,
2016-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p><strong>Aim.</strong> To estimate heart rate variability (HRV) from 5-min and 24-h electrocardiogram (ECG) recordings in female patients with rheumatoid arthritis (RA) and patients of control group, to analyze association between HRV indexes and cardiovascular risk factors and RA-related clinical characteristics.</p><p><strong>Material and Methods.</strong> 90 female patients with RA and 30 healthy subjects matching for age were included in the study. The baseline evaluation included a physical examination, assessment of the cardiovascular risk factors and RA clinical characteristics, laboratory tests, 5-min and 24-hour ECG recordings. We analyzed the time-domain (SDNN, rMSSD, pNN50), frequency-domain (LF, HF, LF/HF ratio) and nonlinear indexes (SD1, SD2, SD21) of HRV from 5-min ECG recording and the time-domain (SDNN, rMSSD, pNN50) indexes from 24-h ECG recordings.</p><p><strong>Results.</strong> Patients with RA had lower HRV in comparison with control subjects (p<0,05). We got the following results for 5-min ECG recordings: time-domain (SDNN, rMSSD, pNN50), frequency-domain (LF, HF) and nonlinear indexes (SD1, SD2) negatively correlated with erythrocyte sedimentation rate (ESR) (р<0,05). All parameters of HRV (except for pNN50) strongly negatively correlated with disease activity score (DAS28). LF and HF levels depended on age. The analysis of 24-h ECG recordings showed negative correlation of timedomain indexes (SDNN, rMSSD, pNN50) with DAS28 and ESR.</p><strong>Conclusion.</strong> Reduced HRV is associated with inflammation activity in patient with RA. Low level of HRV and high RA activity are unfavorable cardiovascular factors. |
|---|---|
| Item Description: | 1819-6446 2225-3653 10.1234/1819-6446-2009-1-77-82 |