Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy
Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders. Recent studies suggest that L-3-n-butylphthalide (NBP), an extract from the seeds of Apium graveolens Linn. (Chinese celery), ameliorates cog...
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| Główni autorzy: | , , , , , , , , , , , , |
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| Format: | Książka |
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Frontiers Media S.A.,
2018-07-01T00:00:00Z.
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| 001 | doaj_c2765d8cab5f43c9a48bf00d7e16698b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xiaowen Ye |e author |
| 700 | 1 | 0 | |a Xiaowen Ye |e author |
| 700 | 1 | 0 | |a Zhouyi Rong |e author |
| 700 | 1 | 0 | |a Yanfang Li |e author |
| 700 | 1 | 0 | |a Xintian Wang |e author |
| 700 | 1 | 0 | |a Xintian Wang |e author |
| 700 | 1 | 0 | |a Xintian Wang |e author |
| 700 | 1 | 0 | |a Baoying Cheng |e author |
| 700 | 1 | 0 | |a Yiyun Cheng |e author |
| 700 | 1 | 0 | |a Yiyun Cheng |e author |
| 700 | 1 | 0 | |a Yiyun Cheng |e author |
| 700 | 1 | 0 | |a Haijuan Luo |e author |
| 700 | 1 | 0 | |a Haijuan Luo |e author |
| 700 | 1 | 0 | |a Yue Ti |e author |
| 700 | 1 | 0 | |a Xiaohua Huang |e author |
| 700 | 1 | 0 | |a Zhaoji Liu |e author |
| 700 | 1 | 0 | |a Zhaoji Liu |e author |
| 700 | 1 | 0 | |a Yun-wu Zhang |e author |
| 700 | 1 | 0 | |a Weihong Zheng |e author |
| 700 | 1 | 0 | |a Weihong Zheng |e author |
| 700 | 1 | 0 | |a Weihong Zheng |e author |
| 700 | 1 | 0 | |a Honghua Zheng |e author |
| 700 | 1 | 0 | |a Honghua Zheng |e author |
| 700 | 1 | 0 | |a Honghua Zheng |e author |
| 245 | 0 | 0 | |a Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy |
| 260 | |b Frontiers Media S.A., |c 2018-07-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2018.00734 | ||
| 520 | |a Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders. Recent studies suggest that L-3-n-butylphthalide (NBP), an extract from the seeds of Apium graveolens Linn. (Chinese celery), ameliorates cognitive dysfunction in ischemia and/or Alzheimer's disease animal models. However, little is known about the role of NBP in epilepsy and the associated comorbidities. Here, using a pilocarpine-induced chronic epileptic mouse model, we found that NBP supplement not only alleviated seizure severity and abnormal electroencephalogram, but also rescued cognitive and emotional impairments in these epileptic mice. The possible underlying mechanisms may be associated with the protective role of NBP in reducing neuronal loss and in restoring the expression of neural synaptic proteins such as postsynaptic density protein 95 (PSD95) and glutamic acid decarboxylase 65/67 (GAD65/67). In addition, NBP treatment increased the transcription of neuroprotective factors, brain-derived neurotrophic factor and Klotho. These findings suggest that NBP treatment may be a potential strategy for ameliorating epileptogenesis and the comorbidities of cognitive and psychological impairments. | ||
| 546 | |a EN | ||
| 690 | |a l-3-n-butylphthalide | ||
| 690 | |a chronic epilepsy | ||
| 690 | |a learning and memory | ||
| 690 | |a anxiety and depression | ||
| 690 | |a protection | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 9 (2018) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2018.00734/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c2765d8cab5f43c9a48bf00d7e16698b |z Connect to this object online. |