Chinese Herbal Medicines Facilitate the Control of Chemotherapy-Induced Side Effects in Colorectal Cancer: Progress and Perspective

Side effects, including nausea, vomiting, mucositis, peripheral neuropathy, and diarrhea, have been frequently reported in colorectal cancer (CRC) patients undergoing chemotherapy. Chinese Herbal Medicines (CHMs) display distinct clinical outcomes, as a result, they have been increasingly used as an...

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Main Authors: Dongmei Chen (Author), Jun Zhao (Author), Weihong Cong (Author)
Format: Book
Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Dongmei Chen  |e author 
700 1 0 |a Dongmei Chen  |e author 
700 1 0 |a Dongmei Chen  |e author 
700 1 0 |a Jun Zhao  |e author 
700 1 0 |a Weihong Cong  |e author 
245 0 0 |a Chinese Herbal Medicines Facilitate the Control of Chemotherapy-Induced Side Effects in Colorectal Cancer: Progress and Perspective 
260 |b Frontiers Media S.A.,   |c 2018-12-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2018.01442 
520 |a Side effects, including nausea, vomiting, mucositis, peripheral neuropathy, and diarrhea, have been frequently reported in colorectal cancer (CRC) patients undergoing chemotherapy. Chinese Herbal Medicines (CHMs) display distinct clinical outcomes, as a result, they have been increasingly used as an adjuvant therapy to manage chemotherapy-induced side effects. In this review, we aim to intensively explore the molecular mechanisms of CHMs, underline the significance of CHMs in mitigating the side effects induced by chemotherapy, and examine the necessary studies required to understand the role of CHMs in alleviating chemotherapy-induced side effects. Specifically, ginger, Astragali Radix, and Liujunzi Decoction have been verified to ameliorate nausea and vomiting. Banxia Xiexin Decoction and Huangqin Decoction have been confirmed to be beneficial to mucositis and delayed-onset of diarrhea. Moreover, Niuche Shenqi Wan, Guilong Tongluo Decoction, Huangqi Guizhi Wuwu Decoction, and tumeric have been found to display potential therapeutic effects for preventing the genesis and development of peripheral neurotoxicity. These findings have further emphasized the pivotal role of CHMs in improving the outcomes of chemotherapy-induced side effects in CRC. Nonetheless, more molecular evidence is required to comprehensively understand and more appropriately apply CHMs in routine clinical practice for CRC. 
546 |a EN 
690 |a Chinese herbal medicine 
690 |a chemotherapy 
690 |a side effects 
690 |a colorectal cancer 
690 |a review 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pharmacology, Vol 9 (2018) 
787 0 |n https://www.frontiersin.org/article/10.3389/fphar.2018.01442/full 
787 0 |n https://doaj.org/toc/1663-9812 
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