Etiological role and molecular-genetic features of <i>Streptococcus pneumoniae</i> in children's infectious diseases

Objective: To study the etiological role, serotype distribution and prevalent Streptococcus pneumoniae genotypes (sequence types) in 459 children hospitalized with acute purulent otitis media, acute tonsillitis, community-acquired pneumonia, and purulent bacterial meningitis. Pneumococcal cultures i...

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Main Authors: I. N. Protasova (Author), G. P. Martynova (Author), N. A. Ilyenkova (Author), I. A. Kutischeva (Author), S. V. Domracheva (Author), O. P. Ovchinnikova (Author), E. S. Sokolovskaya (Author)
Format: Book
Published: LLC "Diagnostics and Vaccines", 2020-03-01T00:00:00Z.
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Summary:Objective: To study the etiological role, serotype distribution and prevalent Streptococcus pneumoniae genotypes (sequence types) in 459 children hospitalized with acute purulent otitis media, acute tonsillitis, community-acquired pneumonia, and purulent bacterial meningitis. Pneumococcal cultures isolated from patients were tested for sensitivity to antimicrobials, and presence of resistance genes.Materials and Methods: The cultural and molecular methods (PCR, sequencing) were used. Statistical analysis was carried out using Microsoft Excel 2007 and Statistica 6.0. Results: S. pneumoniae was detected in 16,8%. The prevalent serotypes were 19F (39.7%) and 19A (13.2%) - representatives of multidrug-resistant clonal com-plex 320. Isolates of serogroup 6 (6AB, 8.82%) belonged to clonal complex 315, and characterized by resistance to macrolides, clindamycin and tetracycline.From 70.6% to 88.2% of S. pneumoniae serotypes isolated from patients corresponded to «vaccine»-types.
Item Description:2072-8107
10.22627/2072-8107-2020-19-1-7-12