"From womb to tomb; we're bound to others": microbiome in forensic science

Microbiome is a new field of interest in clinical medicine with high potential in forensic medicine. It could be used in several applications, such as post-mortem interval (PMI) estimation, personal identification, differential diagnosis of cause of death and toxicology. Regarding PMI, during the de...

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Bibliographic Details
Main Authors: Beatrice Benedetti (Author), Paola Roberti (Author), Marta Ciuffi (Author), Antonio Carai (Author), Ernesto d'Aloja (Author)
Format: Book
Published: Hygeia Press di Corridori Marinella, 2019-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Beatrice Benedetti  |e author 
700 1 0 |a Paola Roberti  |e author 
700 1 0 |a Marta Ciuffi  |e author 
700 1 0 |a Antonio Carai  |e author 
700 1 0 |a Ernesto d'Aloja  |e author 
245 0 0 |a "From womb to tomb; we're bound to others": microbiome in forensic science 
260 |b Hygeia Press di Corridori Marinella,   |c 2019-08-01T00:00:00Z. 
500 |a 2281-0692 
500 |a 10.7363/080215 
520 |a Microbiome is a new field of interest in clinical medicine with high potential in forensic medicine. It could be used in several applications, such as post-mortem interval (PMI) estimation, personal identification, differential diagnosis of cause of death and toxicology. Regarding PMI, during the decomposition of a corpse, the passage of time involves changing in microbial population both outside and inside the corpse but also in surrounding soil (cadaver decomposition island). These variations could be hypothetically used as PMI indicators (microbial clock), even thanks to the development of machine learning approach. Another potential use of skin and saliva microbiome is personal identification thanks to its inter-individual variability and tendency to remain unvarying over time. It may also be helpful to link a person to a specific object that has been touched (microbial fingerprint). Furthermore, we could infer some information about health state of human subjects, comparing post-mortem and ante-mortem microbiome, but this field of research is quite new and needs further studies. Moreover, we have to consider the influence of microbiome metabolism in post-mortem toxicological evaluation; microbes could alter substances concentrations - for example of ethanol, gamma-hydroxybutyric acid (GHB) and nitrobenzodiazepines - due to enzymatic degradation and individual microbial metabolism. Finally, integration of microbiome and human being's transcriptomic analysis may be helpful to depict their complex interactions even after death. 
546 |a EN 
546 |a IT 
690 |a microbiome 
690 |a forensic science 
690 |a pmi 
690 |a personal identification 
690 |a health state 
690 |a toxicology 
690 |a Medicine 
690 |a R 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Journal of Pediatric and Neonatal Individualized Medicine, Vol 8, Iss 2, Pp e080215-e080215 (2019) 
787 0 |n https://www.jpnim.com/index.php/jpnim/article/view/813 
787 0 |n https://doaj.org/toc/2281-0692 
856 4 1 |u https://doaj.org/article/c31673f59e084989b58d01be6a2ec2b7  |z Connect to this object online.