Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer

Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuva...

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Main Authors: Marco Cordani (Author), Esther Resines-Urien (Author), Arturo Gamonal (Author), Paula Milán-Rois (Author), Lionel Salmon (Author), Azzedine Bousseksou (Author), Jose Sanchez Costa (Author), Álvaro Somoza (Author)
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Published: MDPI AG, 2021-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Marco Cordani  |e author 
700 1 0 |a Esther Resines-Urien  |e author 
700 1 0 |a Arturo Gamonal  |e author 
700 1 0 |a Paula Milán-Rois  |e author 
700 1 0 |a Lionel Salmon  |e author 
700 1 0 |a Azzedine Bousseksou  |e author 
700 1 0 |a Jose Sanchez Costa  |e author 
700 1 0 |a Álvaro Somoza  |e author 
245 0 0 |a Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer 
260 |b MDPI AG,   |c 2021-01-01T00:00:00Z. 
500 |a 10.3390/antiox10010066 
500 |a 2076-3921 
520 |a Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively high concentrations and led to an increase in reactive oxygen species (ROS) in two pancreatic cancer cell lines, PANC-1 and BXPC-3, and this effect was accompanied by a significant reduction in cell viability in the presence of gemcitabine (GEM). Importantly, the tested compounds enhanced the effect of GEM, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mTOR pathway. Although further evaluation in animal-based models of pancreatic cancer is needed, these results open novel avenues for exploring these iron-based materials in biomedicine in general and in pancreatic cancer treatment. 
546 |a EN 
690 |a pancreatic cancer 
690 |a antitumor agents 
690 |a coordination polymers 
690 |a bioinorganic chemistry 
690 |a reactive oxygen species 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 10, Iss 1, p 66 (2021) 
787 0 |n https://www.mdpi.com/2076-3921/10/1/66 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/c33f1b79d88444e8b85f5d67e3d13fb2  |z Connect to this object online.