Metabolic profiling reveals therapeutic effects of <it>Herba Cistanches </it>in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'

• Главные авторы: Zhou Mingmei (Автор), Li Xin (Автор), Xie Guoxiang (Автор), Su Mingming (Автор), Chen Minjun (Автор), Qiu Yunping (Автор), Zhao Aihua (Автор), Jiang Jian (Автор), Jia Wei (Автор)
• Формат: ‌
• Опубликовано: BMC, 2008-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Итог

<p>Abstract</p> <p>Background</p> <p><it>Herba Cistanches </it>(<it>Roucongrong</it>) is effective in treating <it>Shenxu Zheng </it>('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear.</p> <p>Methods</p> <p>Using GC-MS-based metabolic profiling, we investigated the metabolic responses to <it>Herba Cistanches </it>intervention in a rat model of the hydrocortisone-induced 'kidney-deficiency syndrome'.</p> <p>Results</p> <p>The metabolic profiles of the rats after hydrocortisone injection deviated from the pre-dose metabolic state at different time points, ranging from day 1 to day 10, whereas the metabolic profiles of the rats treated with both hydrocortisone and water extract of <it>Herba Cistanches </it>returned to the pre-dose state on day 10.</p> <p>Conclusion</p> <p>The intervention of <it>Herba Cistanches </it>caused a systemic recovery from the hydrocortisone-induced metabolic perturbation in rats. This study also demonstrates that metabolic profiling is useful in studying therapeutic mechanisms of herbal medicines.</p>

Примечание

10.1186/1749-8546-3-3
1749-8546