Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells

• Autors principals: Hironori Fujiwara (Autor), Ako Kogure (Autor), Masahiro Sakamoto (Autor), Tohru Yamakuni (Autor), Yoshihiro Mimaki (Autor), Kiyoshi Murata (Autor), Nobuyuki Hitomi (Autor), Kikuji Yamaguchi (Autor), Yasushi Ohizumi (Autor)
• Format: Llibre
• Publicat: Elsevier, 2011-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Sumari

Abstract.: To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription. Keywords:: honeybee royal jelly, CRE-mediated transcription, Alzheimer's disease

Descripció de l’ítem

1347-8613
10.1254/jphs.11001SC