Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA - Benzodiazepine Receptor Complex

• Main Authors: Nobuaki Egashira (Author), Ai Nogami (Author), Katsunori Iwasaki (Author), Ayumi Ishibashi (Author), Naoki Uchida (Author), Kotaro Takasaki (Author), Kenichi Mishima (Author), Ryoji Nishimura (Author), Ryozo Oishi (Author), Michihiro Fujiwara (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract.: In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA - benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation. Keywords:: sleep, social isolation, Yokukansan

Item Description

1347-8613
10.1254/jphs.11079SC