A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

• Main Authors: Daniela S. Contartese (Author), Manuel Rey-Funes (Author), Rafael Peláez (Author), Manuel Soliño (Author), Juan C. Fernández (Author), Ronan Nakamura (Author), Nicolás S. Ciranna (Author), Aníbal Sarotto (Author), Verónica B. Dorfman (Author), Juan J. López-Costa (Author), José M. Zapico (Author), Ana Ramos (Author), Beatriz de Pascual-Teresa (Author), Ignacio M. Larrayoz (Author), César F. Loidl (Author), Alfredo Martínez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous work showed that therapeutic hypothermia prevents retinal damage caused by traumatic neuropathy. We also generated and characterized small molecules that elicit the beneficial effects of hypothermia at normal...