CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells

• Main Authors: Rehana L. Ahmed (Author), Daniel P. Shaughnessy (Author), Todd P. Knutson (Author), Rachel I. Vogel (Author), Khalil Ahmed (Author), Betsy T. Kren (Author), Janeen H. Trembley (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin dependent kinase 11 (CDK11) is a protein kinase that regulates RNA transcription, pre-mRNA splicing, mitosis, and cell death. Targeting of CDK11 expression levels is effective in the experimental treatment of breast and other cancers, but these data are lacking in melanoma. To understand CDK1...