Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters

• Main Authors: Sara Cunha (Author), Cláudia Pina Costa (Author), Joana A. Loureiro (Author), Jorge Alves (Author), Andreia F. Peixoto (Author), Ben Forbes (Author), José Manuel Sousa Lobo (Author), Ana Catarina Silva (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double...