Exonic variants undergoing allele-specific selection in cancers

• Main Authors: Qiyuan Li (Author), Yuanyuan Zeng (Author), Janet Wang (Author), Hongkun Fang (Author), Jintao Guo (Author), Liying Yu (Author), Taoling Zhong (Author), Chaoqun Xu (Author), Matthew Freedman (Author), Thomas LaFramboise (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Allelic imbalance (AI) in tumors is caused by chromosomal and sub-chromosomal gains and losses. Results We evaluated AI at 109,086 germline exonic SNP loci in four cancer types, and identified a set of SNPs that demonstrate strong tumor allele specificity in AI events. Further an...