Wound healing and anti-inflammatory activities of Ceiba pentendra (l.) Gaertn
Background: Traditionally, morphological parts of Ceiba pentandra have been reported as remedies against numerous diseases. On this basis, the wound healing and anti-inflammatory effects of the extract and fractions of Ceiba pentendra was investigated. Methodology: Preliminary qualitative phytochemi...
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| Main Authors: | , , , , |
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| Format: | Book |
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Elsevier,
2022-06-01T00:00:00Z.
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| Summary: | Background: Traditionally, morphological parts of Ceiba pentandra have been reported as remedies against numerous diseases. On this basis, the wound healing and anti-inflammatory effects of the extract and fractions of Ceiba pentendra was investigated. Methodology: Preliminary qualitative phytochemical screening test was performed using HPLC fingerprint analysis. The extract (CPE) and fractions of graded solvent polarity: n-hexane (HXCP), ethylacetate (EACP) and Butanol (BNCP) were investigated for wound-healing potentials, using excision and incision models. Acute and chronic anti-inflammatory properties of C. pentendra were investigated using paw edema and cotton pellet models of inflammation in rats, respectively. Results: HPLC fingerprint analysis revealed the presence of Quercitrin, Apigenin and Catechin phytoconstituents. All the solvent fractions exhibited significant (p<0.05) higher rate of wound healing, contraction and epithelialization, with HXCP-30% fraction being the most active, with total wound healing occurring at the 16th day (100%). The wound breaking strength was significantly greater in groups treated with fractions HXCP-30% and BNCP-30%. In the cotton-pellets studies, the granuloma tissues formed in the extract treated groups were lower than those of the negative control. The result was significant (p<0.05) with CPE at 200 mg/kg and 400 mg/kg. In the paw edema studies, the extracts showed significant anti-inflammatory activities after 2 h with maximum percentage inhibition of 60.00% seen at the sixth hour at 400 mg CPE/kg dose level. Conclusion: The extract and fractions of Ceiba pentendra showed significant wound healing, anti-inflammatory and antibacterial activities which are relevant in explaining the traditional use of the plant in the treatment of wounds. |
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| Item Description: | 2667-1425 10.1016/j.prmcm.2022.100077 |