Methotrexate as a corticosteroid-sparing agent in leprosy reactions: A French multicenter retrospective study.

• Main Authors: Léa Jaume (Author), Estelle Hau (Author), Gentiane Monsel (Author), Antoine Mahé (Author), Antoine Bertolotti (Author), Antoine Petit (Author), Britney Le (Author), Marie Chauveau (Author), Elisabeth Duhamel (Author), Thierry Maisonobe (Author), Martine Bagot (Author), Jean-David Bouaziz (Author), Faïza Mougari (Author), Emmanuelle Cambau (Author), Marie Jachiet (Author), Groupe d'infectiologie en dermatologie et des infections sexuellement transmissibles (GrIDIST) (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Introduction</h4>Leprosy reactions (LRs) are inflammatory responses observed in 30%-50% of people with leprosy. First-line treatment is glucocorticoids (GCs), often administered at high doses with prolonged courses, resulting in high morbi-mortality. Methotrexate (MTX) is an immunomo...