Safety and Efficacy of a Single Procedure of Extraction and Reimplantation of Infected Cardiovascular Implantable Electronic Device (CIED) in Comparison with Deferral Timing: An Observational Retrospective Multicentric Study
(1) Background: Infections are among the most frequent and life-threatening complications of cardiovascular implantable electronic device (CIED) implantation. The aim of this study is to compare the outcome and safety of a single-procedure device extraction and contralateral implantation versus the...
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MDPI AG,
2023-06-01T00:00:00Z.
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| 001 | doaj_c3d409a86bf749f4841d2b4be9bb87e8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Carlo Tascini |e author |
| 700 | 1 | 0 | |a Simone Giuliano |e author |
| 700 | 1 | 0 | |a Vittorio Attanasio |e author |
| 700 | 1 | 0 | |a Luca Segreti |e author |
| 700 | 1 | 0 | |a Andrea Ripoli |e author |
| 700 | 1 | 0 | |a Francesco Sbrana |e author |
| 700 | 1 | 0 | |a Sergio Severino |e author |
| 700 | 1 | 0 | |a Chiara Sordelli |e author |
| 700 | 1 | 0 | |a Sara Hana Weisz |e author |
| 700 | 1 | 0 | |a Agnese Zanus-Fortes |e author |
| 700 | 1 | 0 | |a Gabriele Maria Leanza |e author |
| 700 | 1 | 0 | |a Novella Carannante |e author |
| 700 | 1 | 0 | |a Andrea Di Cori |e author |
| 700 | 1 | 0 | |a Maria Grazia Bongiorni |e author |
| 700 | 1 | 0 | |a Giulio Zucchelli |e author |
| 700 | 1 | 0 | |a Stefano De Vivo |e author |
| 245 | 0 | 0 | |a Safety and Efficacy of a Single Procedure of Extraction and Reimplantation of Infected Cardiovascular Implantable Electronic Device (CIED) in Comparison with Deferral Timing: An Observational Retrospective Multicentric Study |
| 260 | |b MDPI AG, |c 2023-06-01T00:00:00Z. | ||
| 500 | |a 10.3390/antibiotics12061001 | ||
| 500 | |a 2079-6382 | ||
| 520 | |a (1) Background: Infections are among the most frequent and life-threatening complications of cardiovascular implantable electronic device (CIED) implantation. The aim of this study is to compare the outcome and safety of a single-procedure device extraction and contralateral implantation versus the standard-of-care (SoC) two-stage replacement for infected CIEDs. (2) Methods: We retrospectively included 66 patients with CIED infections who were treated at two Italian hospitals. Of the 66 patients enrolled in the study, 27 underwent a single procedure, whereas 39 received SoC treatment. All patients were followed up for 12 months after the procedure. (3) Results: Considering those lost to follow-up, there were no differences in the mortality rates between the two cohorts, with survival rates of 81.5% in the single-procedure group and 84.6% in the SoC group (<i>p</i> = 0.075). (4) Conclusions: Single-procedure reimplantation associated with an active antibiofilm therapy may be a feasible and effective therapeutic option in CIED-dependent and frail patients. Further studies are warranted to define the best treatment regimen and strategies to select patients suitable for the single-procedure reimplantation. | ||
| 546 | |a EN | ||
| 690 | |a CIED infection | ||
| 690 | |a single procedure | ||
| 690 | |a device extraction | ||
| 690 | |a antibiofilm | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antibiotics, Vol 12, Iss 6, p 1001 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/2079-6382/12/6/1001 | |
| 787 | 0 | |n https://doaj.org/toc/2079-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c3d409a86bf749f4841d2b4be9bb87e8 |z Connect to this object online. |