Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking

Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membra...

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Main Authors: Yumi Noda (Author), Sei Sasaki (Author)
Format: Book
Published: Elsevier, 2004-01-01T00:00:00Z.
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700 1 0 |a Sei Sasaki  |e author 
245 0 0 |a Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking 
260 |b Elsevier,   |c 2004-01-01T00:00:00Z. 
500 |a 1347-8613 
500 |a 10.1254/jphs.fmj04004x2 
520 |a Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signaling cascades also induce this sorting. Recently, AQP2-binding proteins that directly regulate this trafficking have been uncovered: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus (NDI). Keywords:: aquaporin-2, PKA phosphorylation, missorting, Rho, cytoskeleton 
546 |a EN 
690 |a Therapeutics. Pharmacology 
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786 0 |n Journal of Pharmacological Sciences, Vol 96, Iss 3, Pp 249-254 (2004) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S1347861319323345 
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