Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membra...
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Elsevier,
2004-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_c3e3d608d78f4f1688ca2b9fd0eba813 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Yumi Noda |e author |
700 | 1 | 0 | |a Sei Sasaki |e author |
245 | 0 | 0 | |a Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking |
260 | |b Elsevier, |c 2004-01-01T00:00:00Z. | ||
500 | |a 1347-8613 | ||
500 | |a 10.1254/jphs.fmj04004x2 | ||
520 | |a Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signaling cascades also induce this sorting. Recently, AQP2-binding proteins that directly regulate this trafficking have been uncovered: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus (NDI). Keywords:: aquaporin-2, PKA phosphorylation, missorting, Rho, cytoskeleton | ||
546 | |a EN | ||
690 | |a Therapeutics. Pharmacology | ||
690 | |a RM1-950 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Journal of Pharmacological Sciences, Vol 96, Iss 3, Pp 249-254 (2004) | |
787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319323345 | |
787 | 0 | |n https://doaj.org/toc/1347-8613 | |
856 | 4 | 1 | |u https://doaj.org/article/c3e3d608d78f4f1688ca2b9fd0eba813 |z Connect to this object online. |