Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Distant metastasis is the major cause of cancer-related mortality in patients with CRC. Epithelial-mesenchymal transition (EMT) is a critical process triggered during tumor metastasis, which is also the main impetus and the e...
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Frontiers Media S.A.,
2022-03-01T00:00:00Z.
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| 700 | 1 | 0 | |a Hongzhang Ge |e author |
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| 700 | 1 | 0 | |a Chao Xu |e author |
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| 700 | 1 | 0 | |a Chao Xu |e author |
| 700 | 1 | 0 | |a Haitao Chen |e author |
| 700 | 1 | 0 | |a Haitao Chen |e author |
| 700 | 1 | 0 | |a Haitao Chen |e author |
| 700 | 1 | 0 | |a Ling Liu |e author |
| 700 | 1 | 0 | |a Ling Liu |e author |
| 700 | 1 | 0 | |a Ling Liu |e author |
| 700 | 1 | 0 | |a Lei Zhang |e author |
| 700 | 1 | 0 | |a Lei Zhang |e author |
| 700 | 1 | 0 | |a Lei Zhang |e author |
| 700 | 1 | 0 | |a Changhong Wu |e author |
| 700 | 1 | 0 | |a Yi Lu |e author |
| 700 | 1 | 0 | |a Qinghua Yao |e author |
| 700 | 1 | 0 | |a Qinghua Yao |e author |
| 700 | 1 | 0 | |a Qinghua Yao |e author |
| 700 | 1 | 0 | |a Qinghua Yao |e author |
| 700 | 1 | 0 | |a Qinghua Yao |e author |
| 245 | 0 | 0 | |a Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms |
| 260 | |b Frontiers Media S.A., |c 2022-03-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.842295 | ||
| 520 | |a Colorectal cancer (CRC) is the third most common type of cancer worldwide. Distant metastasis is the major cause of cancer-related mortality in patients with CRC. Epithelial-mesenchymal transition (EMT) is a critical process triggered during tumor metastasis, which is also the main impetus and the essential access within this duration. Therefore, targeting EMT-related molecular pathways has been considered a novel strategy to explore effective therapeutic agents against metastatic CRC. Traditional Chinese medicines (TCMs) with unique properties multi-target and multi-link that exert their therapeutic efficacies holistically, which could inhibit the invasion and metastasis ability of CRC cells via inhibiting the EMT process by down-regulating transforming growth factor-β (TGF-β)/Smads, PI3K/Akt, NF-κB, Wnt/β-catenin, and Notch signaling pathways. The objective of this review is to summarize and assess the anti-metastatic effect of TCM-originated bioactive compounds and Chinese medicine formulas by mediating EMT-associated signaling pathways in CRC therapy, providing a foundation for further research on the exact mechanisms of action through which TCMs affect EMT transform in CRC. | ||
| 546 | |a EN | ||
| 690 | |a colorectal cancer | ||
| 690 | |a Traditional Chinese medicines | ||
| 690 | |a epithelial-mesenchymal transition | ||
| 690 | |a EMT-related signaling pathways | ||
| 690 | |a tumor metastasis | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.842295/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c404c7d9d9da4d65b3488b0e104efc1e |z Connect to this object online. |