Antifungal Susceptibility Data and Epidemiological Distribution of <i>Candida</i> spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review
Background: Invasive fungal infections represent a concerning healthcare issue, with <i>Candida</i> spp. reported as the main aetiological agent. <i>Candida</i> spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes as a co...
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| Main Authors: | , , |
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| Format: | Book |
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MDPI AG,
2024-09-01T00:00:00Z.
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| Summary: | Background: Invasive fungal infections represent a concerning healthcare issue, with <i>Candida</i> spp. reported as the main aetiological agent. <i>Candida</i> spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes as a contributing feature. Despite the global prevalence of <i>C. albicans</i>, non-<i>albicans</i> species emerged as significant in the last decades. Methods: The present manuscript reports a five-year evaluation on <i>Candida</i> spp. bloodstream isolates and their antifungal susceptibility profiles, aiming to enrich the literature and epidemiological data. Results: According to the gathered data, antifungal-resistance cases remained uncommon. However, the study revealed rare resistance phenotypes such as a single case of pan-echinocandin resistance <i>C. albicans</i>. Conclusions: Finally, a comprehensive review of <i>Candida</i> spp. antifungal resistance integrates the data, emphasizing the extreme species-specific variability and the consequent importance of always providing species identification. |
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| Item Description: | 10.3390/antibiotics13100914 2079-6382 |