Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles

• Main Authors: Juliana Camila Fischer Karnopp (Author), Juliana Jorge (Author), Jaqueline Rodrigues da Silva (Author), Diego Boldo (Author), Kristiane Fanti Del Pino Santos (Author), Adriana Pereira Duarte (Author), Gustavo Rocha de Castro (Author), Ricardo Bentes de Azevedo (Author), Ariadna Lafourcade Prada (Author), Jesús Rafael Rodríguez Amado (Author), Marco Antonio Utrera Martines (Author)
• Formato: Libro
• Publicado: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

This study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy. The nanoparticles were designed with a diameter between 20 and 50 nm to optimize cellular uptake and avoid rapid clearance...