Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes
Abstract Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confidence in the predictive power of such models, they mus...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2023-02-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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