Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto's Thyroiditis

• Main Authors: Fatemeh Esfahanian (Author), Mojgan Mirabdolhagh Hazaveh (Author), Laya Hooshmand Garehbagh (Author), Kowsar Falahati (Author), Mitra Ataei (Author), Mohammad Hossein Sanati (Author), Zohreh Jadali (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto's thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.

Item Description

10.18502/ijph.v50i8.6817
2251-6085
2251-6093