Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

• Main Authors: Essam M. Eissa (Author), Mohammed H. Elkomy (Author), Hussein M. Eid (Author), Adel A. Ali (Author), Mohammed A. S. Abourehab (Author), Amal M. Alsubaiyel (Author), Ibrahim A. Naguib (Author), Izzeddin Alsalahat (Author), Amira H. Hassan (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 (P 407) and Tween 80 (T 80) were used to formulate GS-loaded cubosomes (GS-CBS) utilizing a melt dispersion-emulsificati...