Redox Regulation of Phosphatase and Tensin Homolog by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate in Cell Signaling

• Main Authors: Vu Hoang Trinh (Author), Jin-Myung Choi (Author), Thang Nguyen Huu (Author), Dhiraj Kumar Sah (Author), Hyun-Joong Yoon (Author), Sang-Chul Park (Author), Yu-Seok Jung (Author), Young-Keun Ahn (Author), Kun-Ho Lee (Author), Seung-Rock Lee (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphoinositide 3-kinases/protein kinase B (PI3K/AKT) signaling pathway. Notably, its active site contains a cysteine residue that is susceptible to oxidation by hydrogen peroxide (H₂O₂...