Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents

• Main Authors: Serena Veschi (Author), Simone Carradori (Author), Laura De Lellis (Author), Rosalba Florio (Author), Davide Brocco (Author), Daniela Secci (Author), Paolo Guglielmi (Author), Mattia Spano (Author), Anatoly P. Sobolev (Author), Alessandro Cama (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial agent, we ex...