Serum uric acid, kidney function and acute ischemic stroke outcomes in elderly patients: a single-cohort, perspective study

Chronic kidney disease and hyperuricemia have been associated to an increased risk and a worse prognosis in acute ischemic stroke. Several mechanisms, including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and an increased risk of atrial fibrillation could be i...

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Main Authors: Lorenzo Falsetti (Author), William Capeci (Author), Nicola Tarquinio (Author), Giovanna Viticchi (Author), Mauro Silvestrini (Author), Vania Catozzo (Author), Agnese Fioranelli (Author), Laura Buratti (Author), Francesco Pellegrini (Author)
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Published: MDPI AG, 2017-03-01T00:00:00Z.
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001 doaj_c4b78f9967af4812a7c0967a1c46ee7b
042 |a dc 
100 1 0 |a Lorenzo Falsetti  |e author 
700 1 0 |a William Capeci  |e author 
700 1 0 |a Nicola Tarquinio  |e author 
700 1 0 |a Giovanna Viticchi  |e author 
700 1 0 |a Mauro Silvestrini  |e author 
700 1 0 |a Vania Catozzo  |e author 
700 1 0 |a Agnese Fioranelli  |e author 
700 1 0 |a Laura Buratti  |e author 
700 1 0 |a Francesco Pellegrini  |e author 
245 0 0 |a Serum uric acid, kidney function and acute ischemic stroke outcomes in elderly patients: a single-cohort, perspective study 
260 |b MDPI AG,   |c 2017-03-01T00:00:00Z. 
500 |a 2035-8385 
500 |a 2035-8377 
500 |a 10.4081/ni.2017.6920 
520 |a Chronic kidney disease and hyperuricemia have been associated to an increased risk and a worse prognosis in acute ischemic stroke. Several mechanisms, including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and an increased risk of atrial fibrillation could be implicated. The role of serum uric acid in this setting is still object of debate. We enrolled all the consecutive patients admitted to our department for acute ischemic stroke. Cox regression analysis was used to evaluate the risk of in-hospital death considering serum uric acid levels and all the comorbidities. In the overall sample, hyperuricemia was independently associated to an increased risk of in-hospital mortality. This effect was stronger in patients with chronic kidney disease while, in the group of patients with normal renal function, the relationship between hyperuricemia and increased stroke mortality was not confirmed. Hyperuricemia could be associated to higher in-hospital mortality for ischemic stroke among elderly patients when affected by kidney disease. Survival does not seem to be affected by hyperuricemia in patients with normal kidney function. 
546 |a EN 
690 |a Ischemic stroke 
690 |a Serum uric acid 
690 |a Chronic kidney failure 
690 |a Aging 
690 |a Medicine 
690 |a R 
690 |a Internal medicine 
690 |a RC31-1245 
690 |a Neurosciences. Biological psychiatry. Neuropsychiatry 
690 |a RC321-571 
690 |a Neurosciences. Biological psychiatry. Neuropsychiatry 
690 |a RC321-571 
655 7 |a article  |2 local 
786 0 |n Neurology International, Vol 9, Iss 1 (2017) 
787 0 |n http://www.pagepress.org/journals/index.php/ni/article/view/6920 
787 0 |n https://doaj.org/toc/2035-8385 
787 0 |n https://doaj.org/toc/2035-8377 
856 4 1 |u https://doaj.org/article/c4b78f9967af4812a7c0967a1c46ee7b  |z Connect to this object online.