NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells
NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling. The complex inhibited viability of HeLa cells and induced cell death that was accompanied by loss of mitocho...
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2018-10-01T00:00:00Z.
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| 001 | doaj_c4d5d3b01f194de39e54d282d2b5ee4d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Tatiana Stupina |e author |
| 700 | 1 | 0 | |a Anastasia Balakina |e author |
| 700 | 1 | 0 | |a Tatiana Kondrat'eva |e author |
| 700 | 1 | 0 | |a Galina Kozub |e author |
| 700 | 1 | 0 | |a Natalia Sanina |e author |
| 700 | 1 | 0 | |a Alexei Terent'ev |e author |
| 245 | 0 | 0 | |a NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells |
| 260 | |b MDPI AG, |c 2018-10-01T00:00:00Z. | ||
| 500 | |a 2218-0532 | ||
| 500 | |a 10.3390/scipharm86040046 | ||
| 520 | |a NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling. The complex inhibited viability of HeLa cells and induced cell death that was accompanied by loss of mitochondrial membrane potential and characteristic for apoptosis phosphatidylserine externalization. At IC50, 2-AmPh caused decrease in nuclear content of NF-κB p65 polypeptide and mRNA expression of NF-κB target genes encoding interleukin-8 and anti-apoptotic protein BIRC3. mRNA levels of interleukin-6 and anti-apoptotic protein BIRC2 encoding genes were not affected. Our data demonstrate that NO donating iron nitrosyl complex 2-AmPh can inhibit tumor cell viability and induce apoptosis that is preceded by impairment of NF-κB function and suppression of a subset of NF-κB target genes. | ||
| 546 | |a EN | ||
| 690 | |a iron nitrosyl complex | ||
| 690 | |a 2-aminothiophenyl | ||
| 690 | |a apoptosis | ||
| 690 | |a NF-κB | ||
| 690 | |a p65 | ||
| 690 | |a IL6 | ||
| 690 | |a IL8 | ||
| 690 | |a BIRC2 | ||
| 690 | |a BIRC3 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Scientia Pharmaceutica, Vol 86, Iss 4, p 46 (2018) | |
| 787 | 0 | |n http://www.mdpi.com/2218-0532/86/4/46 | |
| 787 | 0 | |n https://doaj.org/toc/2218-0532 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c4d5d3b01f194de39e54d282d2b5ee4d |z Connect to this object online. |