Physicochemical Properties of a New PEGylated Polybenzofulvene Brush for Drug Encapsulation
A new polymer brush was synthesized by spontaneous polymerization of benzofulvene macromonomer 6-MOEG-9-T-<b>BF3k</b> bearing a nona(ethylene glycol) side chain linked to the 3-phenylindene scaffold by means of a triazole heterocycle. The polymer structure was studied by SEC-MALS, NMR sp...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Book |
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MDPI AG,
2019-09-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_c4d6dce9b66645e1ba75d9b332a6d03a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Marco Paolino |e author |
| 700 | 1 | 0 | |a Annalisa Reale |e author |
| 700 | 1 | 0 | |a Vincenzo Razzano |e author |
| 700 | 1 | 0 | |a Germano Giuliani |e author |
| 700 | 1 | 0 | |a Alessandro Donati |e author |
| 700 | 1 | 0 | |a Gianluca Giorgi |e author |
| 700 | 1 | 0 | |a Antonella Caterina Boccia |e author |
| 700 | 1 | 0 | |a Raniero Mendichi |e author |
| 700 | 1 | 0 | |a Daniele Piovani |e author |
| 700 | 1 | 0 | |a Chiara Botta |e author |
| 700 | 1 | 0 | |a Laura Salvini |e author |
| 700 | 1 | 0 | |a Filippo Samperi |e author |
| 700 | 1 | 0 | |a Cristina Savoca |e author |
| 700 | 1 | 0 | |a Mariano Licciardi |e author |
| 700 | 1 | 0 | |a Eugenio Paccagnini |e author |
| 700 | 1 | 0 | |a Mariangela Gentile |e author |
| 700 | 1 | 0 | |a Andrea Cappelli |e author |
| 245 | 0 | 0 | |a Physicochemical Properties of a New PEGylated Polybenzofulvene Brush for Drug Encapsulation |
| 260 | |b MDPI AG, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 1999-4923 | ||
| 500 | |a 10.3390/pharmaceutics11090444 | ||
| 520 | |a A new polymer brush was synthesized by spontaneous polymerization of benzofulvene macromonomer 6-MOEG-9-T-<b>BF3k</b> bearing a nona(ethylene glycol) side chain linked to the 3-phenylindene scaffold by means of a triazole heterocycle. The polymer structure was studied by SEC-MALS, NMR spectroscopy, and MALDI-TOF MS techniques, and the results supported the role of oligomeric initiatory species in the spontaneous polymerization of polybenzofulvene derivatives. The aggregation features of high molecular weight poly-6-MOEG-9-T-<b>BF3k</b>-FE were investigated by pyrene fluorescence analysis, dynamic light scattering studies, and transmission electron microscopy, which suggested a tendency towards the formation of spherical objects showing dimensions in the range of 20−200 nm. Moreover, poly-6-MOEG-9-T-<b>BF3k</b>-FE showed an interesting cytocompatibility in the whole concentration range tested that, besides its aggregation features, makes this polybenzofulvene brush a good polymer candidate for nanoencapsulation and delivery of drug molecules. Finally, the photo-physical features of poly-6-MOEG-9-T-<b>BF3k</b>-FE could allow the biodistribution of the resulting drug delivery systems to be monitored by fluorescence microscopy techniques. | ||
| 546 | |a EN | ||
| 690 | |a PEGylation | ||
| 690 | |a grafting through | ||
| 690 | |a polybenzofulvene | ||
| 690 | |a nanocarrier | ||
| 690 | |a drug delivery systems | ||
| 690 | |a spontaneous polymerization | ||
| 690 | |a affinity polymerization | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 11, Iss 9, p 444 (2019) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/11/9/444 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c4d6dce9b66645e1ba75d9b332a6d03a |z Connect to this object online. |