Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells

• Main Authors: Silvia Rea (Author), David Della-Morte (Author), Francesca Pacifici (Author), Barbara Capuani (Author), Donatella Pastore (Author), Andrea Coppola (Author), Roberto Arriga (Author), Aikaterini Andreadi (Author), Giulia Donadel (Author), Nicola Di Daniele (Author), Alfonso Bellia (Author), Davide Lauro (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with diabetes mellitus (DM) are more prone to develop cognitive decline and neurodegenerative diseases. A pathological association between an autosomal dominant neurological disorder caused by brain accumulation in mutated huntingtin (mHTT), known as Huntington disease (HD), and DM, has bee...