Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

• Main Authors: Min Yan (Author), Jing Hu (Author), Huating Yuan (Author), Liwen Xu (Author), Gaoming Liao (Author), Zedong Jiang (Author), Jiali Zhu (Author), Bo Pang (Author), Yanyan Ping (Author), Yunpeng Zhang (Author), Yun Xiao (Author), Xia Li (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cells exhibit heterogeneous functional states, which correlate with responsiveness to immune checkpoint blockade and prognosis of tumor patients. However, the molecular regulatory mechanisms underlying the dynamic process of T cell state transition remain largely unknown. Based on single-cell tran...