Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

• Asıl Yazarlar: Yutian Gan (Yazar), Steffen Lippold (Yazar), John Stobaugh (Yazar), Christian Schöneich (Yazar), Feng Yang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Glycosylation affects the safety and efficacy of therapeutic proteins and is often considered a critical quality attribute (CQA). Therefore, it is important to identify and quantify glycans during drug development. Glycosylation is a highly complex post-translational modification (PTM) due to its st...