Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats
Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model...
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| Format: | Book |
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Mashhad University of Medical Sciences,
2017-02-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_c513dba85e5b41febe8ae702e69eee5d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mojtaba Pourzaki |e author |
| 700 | 1 | 0 | |a Mansour Homayoun |e author |
| 700 | 1 | 0 | |a Saeed Sadeghi |e author |
| 700 | 1 | 0 | |a Masoumeh seghatoleslam |e author |
| 700 | 1 | 0 | |a Mahmoud Hosseini |e author |
| 700 | 1 | 0 | |a Alireza Ebrahimzadeh Bideskan |e author |
| 245 | 0 | 0 | |a Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats |
| 260 | |b Mashhad University of Medical Sciences, |c 2017-02-01T00:00:00Z. | ||
| 500 | |a 2228-7930 | ||
| 500 | |a 2228-7949 | ||
| 500 | |a 10.22038/ajp.2016.7757 | ||
| 520 | |a Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.Results: All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p | ||
| 546 | |a EN | ||
| 690 | |a Coriandrum sativum | ||
| 690 | |a Seizure | ||
| 690 | |a Apoptosis | ||
| 690 | |a Neuronal damage | ||
| 690 | |a Hippocampus | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Avicenna Journal of Phytomedicine, Vol 7, Iss 2, Pp 116-128 (2017) | |
| 787 | 0 | |n http://ajp.mums.ac.ir/article_7757_06062e445614ed2f7d8ad7a3d39cf88c.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2228-7930 | |
| 787 | 0 | |n https://doaj.org/toc/2228-7949 | |
| 856 | 4 | 1 | |u https://doaj.org/article/c513dba85e5b41febe8ae702e69eee5d |z Connect to this object online. |