Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives
The current test of acellular Bordetella pertussis (aP) vaccines for residual pertussis toxin (PTx) is the Histamine Sensitization test (HIST), based on the empirical finding that PTx sensitizes mice to histamine. Although HIST has ensured the safety of aP vaccines for years, it is criticized for th...
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| Format: | Book |
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Taylor & Francis Group,
2017-11-01T00:00:00Z.
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