Cover Image

A novel non-linear approach for establishing a QSAR model of a class of 2-Phenyl-3-(pyridin-2-yl) thiazolidin-4-one derivatives

In this investigation, we aimed to address the pressing challenge of treating osteosarcoma, a prevalent and difficult-to-treat form of cancer. To achieve this, we developed a quantitative structure-activity relationship (QSAR) model focused on a specific class of compounds called 2-Phenyl-3-(pyridin...

Full description

Saved in:

Bibliographic Details
Main Authors:	Leilei Wu (Author), Yonglin Chen (Author), Kangying Duan (Author)
Format:	Book
Published:	Frontiers Media S.A., 2023-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives
by: Muhammad Kazim Zargaham, et al.
Published: (2023)

2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential
by: Davinder Kumar, et al.
Published: (2023)

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives
by: A. M. Rud, et al.
Published: (2018)

Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives
by: Davinder Kumar, et al.
Published: (2023)

Synthesis and Anti-Inflammatory Activity of 1-(2,5-Dihydroxyphenyl)-3-Pyridine-2-Yl-Propenone (AEW-1) Compound
by: Andy Eko Wibowo, et al.
Published: (2021)

Molecular docking, ADMET study and in vivo pharmacological research of N-(3,4-dimetoxyphenyl)-2-{[2-methyl-6-(pyridine-2-yl)-pyrimidin-4-yl]thio}acetamide as a promising anticonvulsant
by: Hanna I. Severina, et al.
Published: (2020)

Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties
by: Nazar Trotsko, et al.
Published: (2018)

New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
by: Olga Ciupak, et al.
Published: (2021)

The study of morpholinium 2-[5-(pyridin-4yl)-1,2,4-triazol-3-ylthio]acetate effect on prevention of stressful conditions
by: I. V. Bushueva, et al.
Published: (2014)

Comparative pharmacokinetic study of dosage forms with morpholinium 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate
by: I. V. Bushueva, et al.
Published: (2014)

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives
by: Kim DH, et al.
Published: (2017)

N-Phenyl Ureidobenzenesulfonate derivatives as novel anticancer agents: QSAR and Molecular docking studies
by: Masood Fereidoonnezhad, et al.
Published: (2017)

N-Phenyl Ureidobenzenesulfonate derivatives as novel anticancer agents: QSAR and Molecular docking studies
by: Masood Fereidoonnezhad, et al.
Published: (2017)

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent
by: Jun Wu, et al.
Published: (2021)

QSAR-analysis of 1-[2-(R-phenylimino)-4-methyl-3-(3-[morpholine-4-yl]propyl)-2,3-dihydro-1,3-thiazol-5-yl]ethane-1-one's derivatives as potential antioxidants
by: Іryna Drapak, et al.
Published: (2019)

Design and synthesis of new 3-((7-chloroquinolin-4-yl)amino)thiazolidin-4-one analogs as Mycobacterium tuberculosis DNA gyrase inhibitors
by: Preeti S. Salve, et al.
Published: (2021)

Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3<i>H</i>-thiazolo[4,5-<i>b</i>]pyridin-2-ones
by: Andrii Lozynskyi, et al.
Published: (2021)

Synthesis, physical and chemical properties of esters of 2-((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)ethanoic and 3-(((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)methyl)benzoic acids
by: А. M. Rud, et al.
Published: (2017)

Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl] -3H-pyrido [2,3-d]pyrimidin-4-one derivatives
by: Marzieh Rahmani Khajouei, et al.
Published: (2021)

Antimicrobial Test of 1-(2.5-Dihydroxi Phenyl)-(3-Pyridine-2-Il) -Propanone Compound in Enterococcus Faecalis and Escherichia Coli Bacteria Using a Well Diffusion Method
by: Andy Eko Wibowo, et al.
Published: (2021)

Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts
by: A. S. Hotsulia, et al.
Published: (2020)

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines
by: Ye. O. Karpun, et al.
Published: (2020)

Development of determination method and study of piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio) acetate in milk of cows in 12 hours after administration
by: B. O. Varynskyi, et al.
Published: (2019)

Synthesis, in-vitro antimicrobial and antitubercular screening of Schiff bases of 3-amino-1-phenyl-4- [2-(4-phenyl-1,3-thiazol-2-yl) hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-one
by: K K Sivakumar, et al.
Published: (2013)

Mechanistic interaction study of 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione with bovine serum albumin by spectroscopic and molecular docking approaches
by: Mohammed M. Alanazi, et al.
Published: (2019)

New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
by: Antonella Messore, et al.
Published: (2024)

Synthesis, Characterization and Biological Activity of Some New 4-Substituted-phenyl-3-chloro-1-{5-[(3, 5-dimethyl-1H-pyrazol-1- yl) methyl]-1, 3, 4-thiadiazol-2-yl} azetidin-2-one
by: Rafah Fadhil Al-Smaisim
Published: (2012)

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and antitubercular activity
by: Bijo Mathew, et al.
Published: (2013)

3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors
by: Obaid Afzal, et al.
Published: (2014)

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols
by: Ye. O. Karpun, et al.
Published: (2022)

Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors
by: Adriana M. das Neves, et al.
Published: (2020)

Excipients choice justification for the creation of Adamantane-1ammonium 2-((5-(adamantane-1-yl)-4-phenyl-4H-1,2,4-triazole-3-yl)thio)acetate tablets by the method of wet granulation (part 2)
by: V. M. Odyntsova, et al.
Published: (2017)

Synthesis and study of the properties of derivatives 4-phenyl-5-(1H-pyrrol-2-yl)-4H-1,2,4-triazole-3-thiols
by: A. S. Gotsulya, et al.
Published: (2018)

QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents
by: Masood Fereidoonnezhad, et al.
Published: (2016)

QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents
by: Masood Fereidoonnezhad, et al.
Published: (2016)

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity
by: Bijo Mathew, et al.
Published: (2013)

Synthesis and primary screening of the antioxidant activity of some 4-thioxo- and 4-imino- thiazolidin-2-ones
by: Z. І. Сhulovska, et al.
Published: (2021)

Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs
by: Hayun, et al.
Published: (2012)

Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl)acetamide derivatives for biological evaluation as anticonvulsant agents
by: Mohamed-Kamal Ibrahim, et al.
Published: (2013)

Synthesis and Structure-Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-<i>N</i>-(Pyridin-2-ylmethyl)Pyrazolo[1,5-<i>a</i>]Pyrimidin-7-Amines
by: Hamish S. Sutherland, et al.
Published: (2022)