Development and validation of a UPLC-MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics

• Main Authors: Gang Wang (Author), Dongyang Zhao (Author), Hongxiang Chen (Author), Dawei Ding (Author), Longfa Kou (Author), Lifang Sun (Author), Chenxia Hao (Author), Xincong Li (Author), Kai Jia (Author), Qiming Kan (Author), Xiaohong Liu (Author), Zhonggui He (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple and rapid UPLC-MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative (2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated. The conventional plasm...