Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insu¬lin Level in North Indian Population
<p><strong>Background:</strong> Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene...
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| Main Authors: | , , , |
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| Format: | Book |
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Tehran University of Medical Sciences,
2016-04-01T00:00:00Z.
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| Summary: | <p><strong>Background:</strong> Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes.</p><p><strong>Methods</strong><strong>:</strong> Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method.</p><p><strong>Results</strong><strong>:</strong> The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (<em>P</em><0.05).</p><p><strong>Conclusion</strong><strong>:</strong> GAD<em>-2</em> gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight.</p><p><strong> </strong></p><p><strong>Keywords</strong><strong>: </strong>Obesity, Insulin, GAD-2, Food intake, Polymorphism</p> |
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| Item Description: | 2251-6085 2251-6093 |