Effect of Metformin on Diabetes Mellitus Prevention in Pregnant Women with Risk Factors

• Main Authors: Shirin Niroomanesh (Author), Masoumeh Dadashaliha (Author), Farahnaz Ahmadi (Author), Fatemeh Rahimi Sherbaf (Author), Forough Forghani (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1735-8949; 1735-9392
• Keywords: Gestational diabetes mellitus; Metformin; Prevention; Gynecology and obstetrics; RG1-991
• Source: Journal of Family and Reproductive Health, Vol 4, Iss 4 (2010)

Objective: This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM. Materials and methods: Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI ≥ 30 kg/m2, with normal results in the glucose challenge test (GCT) or the glucose tolerance test (GTT). Subjects were randomly split to two groups; 63 women (group A) who received metformin (500 mg, twice a day) and 126 women (group B) did not use metformin. Incidence of gestational diabetes was compared between two groups. Results: The incidence of gestational diabetes was significantly different between two groups (%1.4 in group A, %15.4 in group B) (p<0.001). The study also showed that the insulin requirement was significantly different between two groups after developing GDM (group A %3.6, group B %9.5, p=0.001). Conclusion: Using Metformin can effectively reduce the incidence of GDM in pregnant women at risk.