The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma

• Main Authors: Wei Liu (Author), Hongmiao Ren (Author), Jihao Ren (Author), Tuanfang Yin (Author), Bing Hu (Author), Shumin Xie (Author), Yinghuan Dai (Author), Weijing Wu (Author), Zian Xiao (Author), Xinming Yang (Author), Dinghua Xie (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholesteatoma is a benign keratinizing and hyper proliferative squamous epithelial lesion of the temporal bone. Epidermal growth factor (EGF) is one of the most important cytokines which has been shown to play a critical role in cholesteatoma. In this investigation, we studied the effects of EGF on...